Sharon, HPP STAR

You probably have some questions about fitting STRENSIQ^® (asfotase alfa) into your routine. If you’re looking for more information, don’t hesitate to talk to your doctor or reach out to OneSource™.

HOW TO STORE STRENSIQ

Since STRENSIQ is an enzyme, it is important to store and handle it correctly.

Store STRENSIQ in its original package in the refrigerator at 36°F to 46°F (2°C to 8°C) until you are ready to use it.

Protect STRENSIQ from light until you are ready to use it.

Remove STRENSIQ from the refrigerator 15 to 30 minutes before use, then be sure to use it within 3 hours.

Do not freeze your STRENSIQ vials. Do not use STRENSIQ if it has been frozen.

Do not shake your STRENSIQ vials.

Do not use STRENSIQ after the expiration date printed on the package.

Remember that STRENSIQ comes in single-use vials, so discard any unused STRENSIQ left in the vial after your injection.

Watch our Traveling with
STRENSIQ FAQ video.

Traveling with
Strensiq

When traveling with STRENSIQ, keep it refrigerated throughout your trip in its original package at 36°F to 46°F (2°C to 8°C). Before you head out on your next getaway, consider the following ideas:

PLAN AHEAD

Gather your injection supplies and check with your destination to make sure there will be a place to refrigerate STRENSIQ when you get there.

KEEP COOL

To maintain its ideal temperature, STRENSIQ may be stored in an insulated cooler with an ice pack. If traveling long distances by plane, call ahead to your airline to find out if refrigeration is provided in-flight.

TSA TRAVEL LETTER

The STRENSIQ starter kit comes with a TSA travel letter explaining what STRENSIQ is and why it's important to remain in your carry on.

HPP PATIENT SUPPORT

Enroll in OneSource™ to get personalized patient support from Alexion at 1.888.765.4747.

Learn More about OneSource™

AT ONESOURCE, WE ARE BY YOUR SIDE THROUGHOUT YOUR JOURNEY, FROM LEARNING ABOUT YOUR CONDITION TO HELPING YOU ACCESS THE THERAPY YOU'VE BEEN PRESCRIBED. PATIENTS' NEEDS ARE OUR TOP PRIORITY.

–Deana,
ONESOURCE CASE MANAGER

READY TO GET STARTED WITH STRENSIQ?

Once your doctor prescribes STRENSIQ, Alexion will be there to guide you every step of
the way. See the resources available as you make STRENSIQ part of your routine.

REQUEST A STRENSIQ PATIENT STARTER KIT

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What is the most important information I should know about STRENSIQ?
Severe allergic (hypersensitivity) reactions have occurred with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting
treatment with STRENSIQ.

What are the possible side effects of STRENSIQ?
STRENSIQ may cause serious side effects, including:
Severe allergic (hypersensitivity) reactions. Allergic reactions are
common with STRENSIQ treatment and can be severe and life threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ.

Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one have any of the signs and symptoms of a severe allergic reaction:

difficulty breathing
choking sensation
swelling of your eyes, lips, or tongue
itching or numbness of the
tongue, lips, cheeks, or gums
dizziness
nausea or vomiting

Call your doctor if you experience any of the following signs and symptoms of an allergic reaction: fever, headache, sweating, feeling irritable, chills, skin redness, skin rash or hives.

Skin thickening or pits at the injection site (lipodystrophy) has happened several months after using STRENSIQ.

Calcium buildup in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up due to disease and may be a side effect of STRENSIQ, although it may also occur in untreated patients. Your healthcare provider should check your eyes and kidneys before and during
treatment with STRENSIQ.

Immune-related effects. You may develop antibodies during
treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including difficulty breathing or walking, feeling tired, bone pain, stiff joints, or loss of appetite.

The most common side effects of STRENSIQ include local skin injection-site reactions (skin redness, bruising, color change, pain, itching, swelling, and bumps).

These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist.

Before using STRENSIQ, tell your healthcare provider about all your medical conditions, including if
you:

have had an allergic reaction to STRENSIQ
are pregnant or plan to become pregnant. It is not known if STRENSIQ will harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use STRENSIQ.

Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins, and herbal supplements.

There is a registry for people who use STRENSIQ. The purpose of this registry is to collect information about HPP and about what happens when you use STRENSIQ for a long time. For more information about this registry, talk with your healthcare provider or go to www.hppregistry.com.

Call your healthcare provider for medical advice about side effects. To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at
1-844-259-6783 or FDA at 1- 800-FDA-1088 or www.fda.gov/
medwatch

Please see the full Prescribing Information, and Patient Information for STRENSIQ
(asfotase alfa), including Boxed
WARNING regarding severe allergic (hypersensitivity) reaction

What is STRENSIQ?
STRENSIQ® (asfotase alfa) is a prescription medicine used to treat people with perinatal, infantile, and juvenile onset hypophosphatasia (HPP).