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KARA, CAREGIVER HPP STAR AND
QUINN, WHO LIVES WITH HPP

Life with HPP

STRENSIQ® (asfotase alfa) is the first and only prescription medicine used to treat people with perinatal/infantile- and juvenile-onset hypophosphatasia (HPP).

Hear about the journey forward from people being treated with STRENSIQ.

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LET’S CONNECT

WHICH BEST
DESCRIBES YOU?

I think I (or someone I care about) could have HPP, but I don’t know the next steps.
I am a person living with or caring for someone with HPP, wanting to learn more about treatment.
I am a person living with or caring for someone with HPP, currently receiving treatment with STRENSIQ.
Talk to someone either living with or caring for someone with HPP.
Listen to an HPP healthcare professional and a patient or caregiver talk about the condition.
Talk to someone either living with or caring for someone with HPP and treating with STRENSIQ.
Learn more about what I can expect with STRENSIQ.
Listen to an HPP healthcare professional and a patient or caregiver talk about STRENSIQ.
Learn more about starting or administering STRENSIQ.
Talk to someone either living with or caring for someone with HPP and treating with STRENSIQ.
Listen to an HPP healthcare professional and a patient or caregiver talk about STRENSIQ.
Learn more about what I can expect with STRENSIQ.
Receive guidance on administering STRENSIQ.

Want information about HPP?

We recommend THAT YOU…

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Attend an HPP Educational Event

Register to attend an educational, no-cost HPP webinar and/or live event. You’ll hear from someone whose life has been impacted by HPP, as well as a healthcare provider specializing in HPP.

Register now
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Connect with OneSource™

OneSource™ is a complimentary, personalized patient support program offered by Alexion. When you enroll in the program, you’ll work with a dedicated team of people with expertise in rare conditions and health insurance.

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REQUEST A STARTER KIT

Coping with HP

Fill out the form below to connect with an HPP STAR.

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THANK YOU

Your request has been submitted and you will be hearing from an HPP STAR shortly.

Hypophosphatasia (HPP) is often misdiagnosed as other conditions. But the more physicians out there, the more parents out there that are aware of the symptoms, they can ask about it and potentially get a correct diagnosis quicker than they otherwise would.”

Becky, Caregiver HPP STAR

We all have our challenges, and HPP is mine. If I can help someone else because of my experiences, I am grateful.”

Sharon, HPP STAR

I think the Peer Connects program is a nice way to communicate with patients on a one-on-one basis, hear their story, share our story, and really just help people through their diagnosis.”

Becky, Caregiver HPP STAR

HPP Support

Explore support options, find helpful downloads,
and meet other people living with HPP.

HPP Resources

courage TO USE Strensiq

STRENSIQ is an injectable prescription medication
you can take at home as part of your routine.

HOW TO USE STRENSIQ

Life with strensiq

When I think about the journey that Quinn has been on and continues on, I see him finding his sense of independence—every day, every week, every year.”

Kara, Caregiver HPP STAR

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IMPORTANT SAFETY
INFORMATION INCLUDING BOXED
WARNING & INDICATION

IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING

What is the most important information I should know about STRENSIQ?
Severe allergic (hypersensitivity) reactions have occurred with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting
treatment with STRENSIQ.

What are the possible side effects of STRENSIQ?
STRENSIQ may cause serious side effects, including:
Severe allergic (hypersensitivity) reactions. Allergic reactions are
common with STRENSIQ treatment and can be severe and life threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ.

Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one have any of the signs and symptoms of a severe allergic reaction:

  • difficulty breathing
  • choking sensation
  • swelling of your eyes, lips, or tongue
  • itching or numbness of the
    tongue, lips, cheeks, or gums
  • dizziness
  • nausea or vomiting

Call your doctor if you experience any of the following signs and symptoms of an allergic reaction: fever, headache, sweating, feeling irritable, chills, skin redness, skin rash or hives.

Skin thickening or pits at the injection site (lipodystrophy) has happened several months after using STRENSIQ.

Calcium buildup in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up due to disease and may be a side effect of STRENSIQ, although it may also occur in untreated patients. Your healthcare provider should check your eyes and kidneys before and during
treatment with STRENSIQ.

Immune-related effects. You may develop antibodies during
treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including difficulty breathing or walking, feeling tired, bone pain, stiff joints, or loss of appetite.

The most common side effects of STRENSIQ include local skin injection-site reactions (skin redness, bruising, color change, pain, itching, swelling, and bumps).

These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist.

Before using STRENSIQ, tell your healthcare provider about all your medical conditions, including if
you:

  • have had an allergic reaction to STRENSIQ
  • are pregnant or plan to become pregnant. It is not known if STRENSIQ will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use STRENSIQ.

Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins, and herbal supplements.

There is a registry for people who use STRENSIQ. The purpose of this registry is to collect information about HPP and about what happens when you use STRENSIQ for a long time. For more information about this registry, talk with your healthcare provider or go to www.hppregistry.com.

Call your healthcare provider for medical advice about side effects. To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at
1-844-259-6783 or FDA at 1- 800-FDA-1088 or www.fda.gov/
medwatch

Please see the full Prescribing Information, and Patient Information for STRENSIQ
(asfotase alfa), including Boxed
WARNING regarding severe allergic (hypersensitivity) reaction

INDICATION

What is STRENSIQ?
STRENSIQ® (asfotase alfa) is a prescription medicine used to treat people with perinatal, infantile, and juvenile onset hypophosphatasia (HPP).

IMPORTANT SAFETY
INFORMATION INCLUDING BOXED
WARNING & INDICATION

IMPORTANT SAFETY INFORMATION INCLUDING BOXED WARNING

What is the most important information I should know about STRENSIQ?
Severe allergic (hypersensitivity) reactions have occurred with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting
treatment with STRENSIQ.

What are the possible side effects of STRENSIQ?
STRENSIQ may cause serious side effects, including:
Severe allergic (hypersensitivity) reactions. Allergic reactions are
common with STRENSIQ treatment and can be severe and life threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ.

Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one have any of the signs and symptoms of a severe allergic reaction:

  • difficulty breathing
  • choking sensation
  • swelling of your eyes, lips, or tongue
  • itching or numbness of the
    tongue, lips, cheeks, or gums
  • dizziness
  • nausea or vomiting

Call your doctor if you experience any of the following signs and symptoms of an allergic reaction: fever, headache, sweating, feeling irritable, chills, skin redness, skin rash or hives.

Skin thickening or pits at the injection site (lipodystrophy) has happened several months after using STRENSIQ.

Calcium buildup in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up due to disease and may be a side effect of STRENSIQ, although it may also occur in untreated patients. Your healthcare provider should check your eyes and kidneys before and during
treatment with STRENSIQ.

Immune-related effects. You may develop antibodies during
treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including difficulty breathing or walking, feeling tired, bone pain, stiff joints, or loss of appetite.

The most common side effects of STRENSIQ include local skin injection-site reactions (skin redness, bruising, color change, pain, itching, swelling, and bumps).

These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist.

Before using STRENSIQ, tell your healthcare provider about all your medical conditions, including if
you:

  • have had an allergic reaction to STRENSIQ
  • are pregnant or plan to become pregnant. It is not known if STRENSIQ will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use STRENSIQ.

Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins, and herbal supplements.

There is a registry for people who use STRENSIQ. The purpose of this registry is to collect information about HPP and about what happens when you use STRENSIQ for a long time. For more information about this registry, talk with your healthcare provider or go to www.hppregistry.com.

Call your healthcare provider for medical advice about side effects. To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at
1-844-259-6783 or FDA at 1- 800-FDA-1088 or www.fda.gov/
medwatch

Please see the full Prescribing Information, and Patient Information for STRENSIQ
(asfotase alfa), including Boxed
WARNING regarding severe allergic (hypersensitivity) reaction

INDICATION

What is STRENSIQ?
STRENSIQ® (asfotase alfa) is a prescription medicine used to treat people with perinatal, infantile, and juvenile onset hypophosphatasia (HPP).